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Ketamine Research and Resources

Yale University (2000 and beyond): The landmark research led by Dr. John Krystal first showed ketamine’s ability to relieve depression symptoms — often within hours rather than weeks. Yale Ketamine Research

Mechanism of Action: Strong scientific reviews confirm ketamine’s effects on BDNF, mTOR, and glutamate pathways that drive rapid and lasting brain changes. Key 2024 Neuroplasticity Review

PTSD

Ketamine-assisted psychotherapy has shown strong promise for treatment-resistant PTSD.

  • A randomized controlled trial found repeated ketamine infusions significantly reduced PTSD symptom severity in patients with chronic PTSD. Feder et al., 2021
  • Real-world data from over 8,000 patients showed clinically meaningful reductions in PTSD symptoms following ketamine therapy. McInnes et al., 2025
  • Systematic reviews support ketamine’s effectiveness for PTSD. Almeida et al., 2024 Systematic Review

Substance Use Disorders (Including Alcohol Use Disorder)

Ketamine, especially when paired with psychotherapy, shows promising results for treating addiction and supporting
recovery.

Recommended Books

  • The Ketamine Handbook by Janelle Lassalle View Book
  • The Ketamine Papers edited by Phil Wolfson, M.D. View Book
  • The Ketamine Breakthrough by Dr. Mike Dow & Ronan Levy View Book
  • The Psychedelic Explorer’s Guide by James Fadiman View Book

Recommended Videos

  • John Krystal, MD (Yale) – “Ketamine with John Krystal” Watch on YouTube
  • Journey Clinical – Official demo of a KAP dosing session Watch on YouTube
  • “Understanding Ketamine-Assisted Psychotherapy (KAP)” with Jonah Mishaan Watch on YouTube
  • New York Times: “Ketamine Therapy Offers Hope for a Firefighter” (short documentary) Watch the NYT Op-Doc

Begin Your Ketamine Therapy Journey in Westport, CT

Conventional treatments have limits. When you’ve reached those limits, ketamine therapy at Mindflow Therapy offers a neurologically grounded, therapeutically integrated path forward — designed for people ready to address the roots of what they’re experiencing.

Start with a complimentary 15-minute consultation. It costs nothing and may change everything.